KISSPEPTIN-10

Kisspeptin-10

Kisspeptin-10 is the shortest biologically active form of kisspeptin, a family of peptides encoded by the KISS1 gene. It corresponds to the final ten residues of the 54-amino-acid kisspeptin-54 and keeps the amidated Arg-Phe-NH₂ C-terminus that all kisspeptins share. The gene was first described in 1996 as a metastasis suppressor in melanoma cells; its peptide products were identified in 2001 as the natural ligands of the orphan receptor GPR54, now called KISS1R.

Product Specifications

• Product: Kisspeptin-10
• Amount: See available options above
• Form: Lyophilized powder
• Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
• Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
• Ships from: United States, 2-day UPS

Chemical Profile

• Compound class: Decapeptide, C-terminal fragment of kisspeptin (KISS1R agonist)
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (human kisspeptin-10)
• Molecular formula: C₆₃H₈₃N₁₇O₁₄
• Molecular weight: 1302.4 g/mol
• CAS number: 374675-21-5

What researchers study

KISS1R is a G protein-coupled receptor that signals through G_q/11, activating phospholipase C, intracellular calcium release and ERK1/2. In 2003, two groups reported that loss-of-function mutations in this receptor are associated with absent puberty in humans and in knockout mice. That finding placed kisspeptin signaling upstream of gonadotropin-releasing hormone (GnRH) and turned it into one of the central topics in reproductive neuroendocrinology.

Research areas where Kisspeptin-10 is used as a reference agonist include:

• GnRH neuron physiology: electrophysiology and hormone-release studies in hypothalamic slices and explants, and in immortalized GnRH cell lines.
• The hypothalamic-pituitary-gonadal axis: rodent and sheep models of how kisspeptin neurons in the arcuate and anteroventral periventricular nuclei relay sex-steroid feedback.
• Receptor pharmacology: structure-activity work on the decapeptide and design of longer-acting KISS1R analogs and antagonists.
• Peripheral kisspeptin biology: KISS1R expression in the pancreas, placenta and vasculature, including studies of insulin secretion and glucose homeostasis.
• Cancer biology: the original metastasis-suppressor role of KISS1 in tumor cell lines.

Regulatory status

Kisspeptin-10 is not approved by the FDA for any use. Kisspeptin peptides have been evaluated in clinical research studies, but no kisspeptin drug product is approved. The material sold here is a research reagent only.

Quality & Documentation

Every batch of Kisspeptin-10 is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). Each vial is labeled with its batch number and a QR code that opens the testing lab’s own report for that batch. The same batch Certificate of Analysis is posted on this page and in our COA Library, so you can check one against the other.

Research overview

For a longer look at Kisspeptin-10, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our Kisspeptin-10 research overview. It is written as background reading, and every study it cites is linked to PubMed.

Selected literature

• Ohtaki T, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411(6837):613-617. PMID 11385580
• Seminara SB, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614-1627. PMID 14573733
• Messager S, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA. 2005;102(5):1761-1766. PMID 15665093
• Izzi-Engbeaya C, Hill TG, Bowe JE. Kisspeptin and glucose homeostasis. Semin Reprod Med. 2019. PMID 31869842
• Xie Q, et al. The role of kisspeptin in the control of the hypothalamic-pituitary-gonadal axis and reproduction. Front Endocrinol (Lausanne). 2022;13:925206. PMID 35837314

Research Use Only

This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.