CAGRILINTIDE

Cagrilintide

Cagrilintide is a long-acting synthetic analog of amylin, the 37-amino-acid peptide hormone that pancreatic β-cells co-secrete with insulin. Native human amylin is a difficult research reagent because it aggregates readily into amyloid fibrils. Cagrilintide was engineered with amino-acid substitutions that reduce that tendency and with a fatty-acid side chain that binds serum albumin and extends its half-life. It is part of the Rogue Compounds GLP Collection and is supplied as a lyophilized powder.

Product Specifications

• Product: Cagrilintide
• Amount: See available options above
• Form: Lyophilized powder
• Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
• Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
• Ships from: United States, 2-day UPS

Chemical Profile

• Compound class: Synthetic acylated amylin analog peptide
• Molecular formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
• Molecular weight: 4409.0 g/mol
• CAS number: 1415456-99-3

The receptor biology

Amylin acts through a receptor system built from two parts. The calcitonin receptor (CTR), a class B G protein-coupled receptor, can pair with one of three receptor activity-modifying proteins (RAMP1, 2 or 3). The resulting complexes, AMY₁, AMY₂ and AMY₃, respond to amylin with high potency, while CTR alone prefers calcitonin. Signaling runs mainly through G_s and cAMP. Amylin receptors are concentrated in the area postrema and other hindbrain regions, which are central to studies of satiety signaling and gastric emptying.

What researchers study

• Receptor pharmacology: potency and efficacy at AMY receptors versus CTR in cells co-expressing defined RAMPs, measured by cAMP accumulation and receptor-binding assays. Cagrilintide acts at both amylin and calcitonin receptors.
• Peptide engineering: how substitutions and acylation change fibrillation, solubility and plasma stability compared with native amylin.
• Hindbrain signaling: rodent studies of area postrema activation and food-intake regulation.
• Combination pharmacology: preclinical models pairing amylin-receptor and GLP-1-receptor agonism to study how the two pathways interact.

Regulatory status

Cagrilintide is an investigational compound developed by Novo Nordisk. It has been evaluated in clinical studies, alone and in combination with a GLP-1 receptor agonist, and it is not approved by the FDA as a standalone drug. The material sold here is a research reagent only.

Quality & Documentation

Every batch of Cagrilintide is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). Each vial is labeled with its batch number and a QR code that opens the testing lab’s own report for that batch. The same batch Certificate of Analysis is posted on this page and in our COA Library, so you can check one against the other.

Research overview

For a longer look at Cagrilintide, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our Cagrilintide research overview. It is written as background reading, and every study it cites is linked to PubMed.

Selected literature

• Hay DL, et al. Amylin: pharmacology, physiology, and clinical potential. Pharmacol Rev. 2015;67(3):564-600. PMID 26071095
• Kruse T, et al. Development of cagrilintide, a long-acting amylin analogue. J Med Chem. 2021;64(15):11183-11194. PMID 34288673
• Boyle CN, Lutz TA, Le Foll C. Amylin – its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity. Mol Metab. 2018;8:203-210. PMID 29203236

Research Use Only

This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.