DSIP

DSIP

DSIP, delta sleep-inducing peptide, is a nonapeptide first isolated in the 1970s by a Swiss group from the cerebral venous blood of rabbits during electrically induced sleep, and named for its reported effect on delta-wave EEG activity. Despite decades of study, no gene, precursor protein or specific receptor for DSIP has been identified, which makes it an unusual case among neuropeptides.

Product Specifications

• Product: DSIP
• Amount: See available options above
• Form: Lyophilized powder
• Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
• Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
• Ships from: United States, 2-day UPS

Chemical Profile

• Compound class: Linear nonapeptide
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (9 residues)
• Molecular formula: C₃₅H₄₈N₁₀O₁₅
• Molecular weight: 848.8 g/mol
• CAS number: 62568-57-4

What researchers study

Reviews have called DSIP “a still unresolved riddle”: it has been reported to act in many systems, but its physiological role remains unclear. Research directions include:

• EEG and sleep architecture: rabbit, rat and cat studies of slow-wave and paradoxical sleep, with findings that differ between species and laboratories.
• Neuroendocrine regulation: rat studies of luteinizing hormone, corticotropin and growth hormone release, and of pineal N-acetyltransferase activity through α₁-adrenergic receptors.
• Mitochondria and hypoxia: isolated rat brain mitochondria and experimental hypoxia models measuring respiration and oxidative phosphorylation.
• Glutamate signaling: neuronal recordings suggesting that some DSIP effects involve NMDA receptors.
• Stability and analogues: DSIP is cleaved quickly by aminopeptidase-like enzymes in vitro, and modified analogues have been made to study structure-activity relationships.

The literature is old, fragmented and often contradictory. Findings in animal and tissue models do not establish effects in humans.

Regulatory status

DSIP is not approved by the FDA for any use. It is sold here as a research reagent only.

Quality & Documentation

Every batch of DSIP is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). The batch Certificate of Analysis is posted on this page and in our COA Library, so the vial in your lab can be matched to its report.

Research overview

For a longer look at DSIP, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our DSIP research overview. It is written as background reading, and every study it cites is linked to PubMed.

Selected literature

• Monnier M, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977;33(4):548-552. PMID 862769
• Graf MV, Schoenenberger GA. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the α1-adrenergic receptor. J Neurochem. 1987;48(4):1252-1257. PMID 3029331
• Yehuda S, Carasso RL. DSIP—a tool for investigating the sleep onset mechanism: a review. Int J Neurosci. 1988;38(3-4):345-353. PMID 3286557
• Khvatova EM, et al. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003;24(2):307-311. PMID 12668217
• Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. PMID 16539679

Research Use Only

This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.