Rogue Research Department

Ipamorelin — Research Overview Chemical Name: Ipamorelin Also Known As: NNC-26-0161, ipamorelin acetate (salt form) Amino Acid Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 Structure: Synthetic pentapeptide (5 amino acids) GHS-R1a agonist. Notably contains alpha-aminoisobutyric acid (Aib) at position 1 — a non-natural amino acid that does not occur in the GHRP-6 or GHRP-2 scaffolds — and was identified through […]

GHRP-6 — Research Overview Chemical Name: Growth Hormone-Releasing Peptide-6 (GHRP-6) Amino Acid Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 Structure: Synthetic hexapeptide analog of met-enkephalin. Contains two D-amino acids (D-Trp at position 2 and D-Phe at position 5) conferring proteolytic resistance and receptor binding affinity. Molecular Formula: C46H56N12O6 Molecular Weight: 873.0 daltons Historical Significance: GHRP-6 was the first synthetic GH

GHRP-2 — Research Overview Chemical Name: Growth Hormone-Releasing Peptide-2 (GHRP-2) International Nonproprietary Name: Pralmorelin Also Known As: GHRP-2, pralmorelin, pralmorelin hydrochloride, KP-102, GPA-748 Amino Acid Sequence: D-Ala-D-(β-naphthyl)-Ala-Ala-Trp-D-Phe-Lys-NH2 Structure: Synthetic hexapeptide (6 amino acids) — an analog of met-enkephalin engineered for potent GHS-R1a agonist activity. Contains D-amino acids at positions 1, 2, and 4 for proteolytic

Glutathione — Research Overview Chemical Name: Gamma-L-glutamyl-L-cysteinyl-glycine Also Known As: GSH, reduced glutathione, L-glutathione, GSH, the master antioxidant Structure: Tripeptide composed of three amino acids — glutamic acid, cysteine, and glycine — linked by peptide bonds. The cysteine residue contains the reactive thiol (-SH) group responsible for glutathione’s antioxidant and detoxification functions. Molecular Formula: C10H17N3O6S

HMG (Human Menopausal Gonadotropin) — Research Overview Chemical Name: Human Menopausal Gonadotropin (hMG) Also Known As: HMG, hMG, menotropins, Pergonal (original brand), Menopur, Menogon, Repronex Source: Urinary extract from the urine of postmenopausal women, which contains elevated levels of FSH and LH due to the loss of negative feedback from ovarian estrogen and inhibin at

IGF-1 LR3 — Research Overview Chemical Name: Long Arg3 Insulin-Like Growth Factor-1 (LR3-IGF-I) Also Known As: IGF-1 LR3, LR3-IGF-1, Long R3 IGF-1, Long arginine 3-IGF-1 Structure: 83-amino acid synthetic analog of human insulin-like growth factor-1 (IGF-1), modified by two structural changes from native IGF-1: substitution of glutamic acid with arginine at position 3 (the Arg3

IGF-DES — Research Overview Chemical Name: Des(1-3) Insulin-Like Growth Factor-1 Also Known As: IGF-1 DES, IGF-DES, Des(1-3)IGF-I, des-IGF-1, Truncated IGF-1 Structure: 67-amino acid truncated analog of human insulin-like growth factor-1, produced by removal of the first three N-terminal amino acids — the tripeptide Gly-Pro-Glu — from the 70-amino acid native IGF-1 sequence. This creates a

HGH Fragment 176-191 — Research Overview Chemical Name: Human growth hormone C-terminal fragment, amino acids 176 to 191 Also Known As: HGH Frag 176-191, GH Fragment 176-191, hGH 176-191, the lipolytic fragment Peptide Sequence: Tyr-Leu-Ala-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe Molecular Formula: C78H125N23O23S2 Molecular Weight: 1817.12 daltons Structure: 16-amino acid synthetic peptide corresponding to the native C-terminal sequence of human

Tirzepatide — Research Overview Chemical Name: LY3298176 (development code); tirzepatide (INN) Brand Names: Mounjaro (FDA-approved for type 2 diabetes, May 2022), Zepbound (FDA-approved for chronic weight management, November 2023; approved for obstructive sleep apnea, December 2024) Developer: Eli Lilly and Company Structure: Synthetic 39-amino acid peptide based on the native glucose-dependent insulinotropic polypeptide (GIP) sequence,

FOXO4-DRI — Research Overview Chemical Name: FOXO4 D-Retro-Inverso peptide Also Known As: FOXO4-DRI, FOXO4-p53 senolytic peptide Structure: Synthetic peptide derived from the p53-interaction domain of the FOXO4 forkhead transcription factor, modified using the D-retro-inverso (DRI) approach in which all L-amino acids are replaced by their D-enantiomers and the peptide sequence is reversed. This dual modification