PE-22-28 is a synthetic peptide fragment derived from spadin, which itself is a natural peptide generated from the maturation of sortilin. Research suggests PE-22-28 functions as a potent antagonist of the TREK-1 potassium channel, a target implicated in depression and mood regulation. By blocking TREK-1 activity, PE-22-28 has been investigated for its potential to produce antidepressant and anxiolytic effects with a rapid onset compared to traditional therapies.
Preclinical studies also indicate possible neuroprotective properties, making PE-22-28 a candidate for research into stress-related disorders, mood regulation, and cognitive health. Its mechanism of targeting ion channel activity and neurotrophic pathways distinguishes it from conventional antidepressant models.
