EPITHALON

Epithalon

Epithalon (also spelled Epitalon; sequence AEDG) is a synthetic tetrapeptide developed in Russia as a defined, synthetic counterpart to epithalamin, a peptide extract prepared from bovine pineal glands. At four residues and about 390 g/mol, it is one of the smallest peptides in the group of short “bioregulator” peptides studied by Russian gerontology laboratories since the 1980s.

Product Specifications

• Product: Epithalon
• Amount: See available options above
• Form: Lyophilized powder
• Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
• Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
• Ships from: United States, 2-day UPS

Chemical Profile

• Compound class: Synthetic tetrapeptide
• Sequence: Ala-Glu-Asp-Gly (4 residues)
• Molecular formula: C₁₄H₂₂N₄O₉
• Molecular weight: 390.35 g/mol
• CAS number: 307297-39-8

What researchers study

Epithalon research is concentrated around the pineal gland and the biology of aging, mostly in cell cultures, rodents and invertebrates:

• Pineal function: studies of melatonin secretion by the pineal glands of young and old rats, and of pineal activity under different light regimens.
• Gene expression and epigenetics: cell-culture work proposing that very short peptides can enter the nucleus and interact with DNA and histones, with readouts such as neurogenesis-related gene and protein expression.
• Lifespan models: survival and antioxidant-enzyme studies in Drosophila melanogaster and in rodents, including studies of spontaneous tumor incidence.
• Retinal and wound models: in-vitro models of diabetic retinopathy and older work in retinal degeneration models.
• Telomere biology: cell-culture studies of telomerase activity and telomere length.

Most of this work comes from a small network of related laboratories, and independent replication is limited. A 2025 review summarizes the field. Findings in cells, flies and rodents do not establish effects in humans.

Regulatory status

Epithalon is not approved by the FDA for any use. It is sold here as a research reagent only.

Quality & Documentation

Every batch of Epithalon is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). Each vial is labeled with its batch number and a QR code that opens the testing lab’s own report for that batch. The same batch Certificate of Analysis is posted on this page and in our COA Library, so you can check one against the other.

Research overview

For a longer look at Epithalon, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our Epithalon research overview. It is written as background reading, and every study it cites is linked to PubMed.

Selected literature

• Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) on melatonin secretion by the pineal gland of young and old rats. PMID 12809170
• Effect of epitalon on the lifespan increase in Drosophila melanogaster. PMID 11087911
• AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism. PMID 32019204
• The antioxidant tetrapeptide epitalon enhances delayed wound healing in an in vitro model of diabetic retinopathy. PMID 40493162
• Overview of Epitalon—highly bioactive pineal tetrapeptide with promising properties. PMID 40141333

Research Use Only

This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.