5-AMINO-1MQ Capsules
This listing supplies 5-Amino-1MQ, the quinolinium-based nicotinamide N-methyltransferase (NNMT) inhibitor, as dry-filled capsules rather than loose powder. The capsule format gives a laboratory pre-portioned solid units that are packed in a sealed mylar pouch and stored at room temperature, which simplifies inventory and avoids weighing small amounts of a fine powder at the bench. The fill amount per capsule is shown in the product options and on the batch COA.
Product Specifications
- Product: 5-AMINO-1MQ Capsules
- Amount: See available options above
- Form: Capsules (dry fill), shipped in a sealed mylar pouch
- Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
- Storage: Keep sealed at room temperature (20–25°C), away from heat, moisture and light.
- Ships from: United States, 2-day UPS
Chemical Profile
- Compound class: Small-molecule quinolinium compound
- Molecular formula: C10H11N2+ (cation)
- Molecular weight: 159.21 g/mol (cation)
- CAS number: 685079-15-6
Format notes
- Salt form: quaternary quinolinium compounds carry a permanent positive charge and are isolated as salts. The formula and weight above describe the cation; check the COA for the counterion when calculating molar amounts.
- Moisture and light: the mylar pouch is a barrier against humidity and light. Reseal it promptly and keep it away from heat.
- Capsule contents: capsules are dry fill. Any excipient used in the fill is identified on the batch documentation.
Background on the compound
5-Amino-1MQ was identified in a structure-activity study that screened a series of quinolinium analogs against NNMT, the enzyme that methylates nicotinamide using S-adenosylmethionine. Researchers compared how substitutions around the quinolinium ring changed binding in the enzyme’s nicotinamide pocket, and 5-amino-substituted analogs were among the more potent inhibitors in that series.
Follow-up preclinical work examined the compound in cultured adipocytes and in diet-induced obese mice, measuring 1-methylnicotinamide, intracellular NAD+ and SAM, and adipose tissue readouts. A separate rodent study looked at muscle stem cells in aged mice, asking whether NNMT inhibition changes their activity in injury models. All published work is preclinical.
Regulatory status
5-Amino-1MQ is not approved by the FDA and has not been approved for human use. It is sold here as a research reagent only.
Quality & Documentation
Every batch of 5-AMINO-1MQ is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). The batch Certificate of Analysis is posted on this page and in our COA Library, so the pouch in your lab can be matched to its report.
Selected literature
- Neelakantan H, et al. Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J Med Chem. 2017;60(12):5015-5028. PMID 28548833
- Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. PMID 29155147
- Neelakantan H, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. PMID 30753815
Research Use Only
This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.
