5-AMINO-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small, positively charged quinolinium compound studied as a selective, membrane-permeable inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It came out of structure-activity work on quinolinium scaffolds published in 2017 and 2018. This listing is the lyophilized powder, offered in 50mg and 100mg amounts.
Product Specifications
- Product: 5-AMINO-1MQ
- Amount: 50mg / 100mg
- Form: Lyophilized powder
- Purity: Third-party tested by an ISO 17025 U.S. laboratory. The batch Certificate of Analysis (COA) is posted on this page when the batch is in stock.
- Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
- Ships from: United States, 2-day UPS
Chemical Profile
- Compound class: Small-molecule quinolinium compound (NNMT inhibitor)
- Molecular formula: C10H11N2+ (cation)
- Molecular weight: 159.21 g/mol (cation)
- CAS number: 685079-15-6
The enzyme target
NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine. The reaction sits at a junction of two pathways:
- Methyl metabolism: every turnover uses one SAM, the cell’s main methyl donor, so NNMT activity can affect the methylation potential available for histones and other substrates.
- NAD+ salvage: methylated nicotinamide cannot be recycled into NAD+, so NNMT diverts nicotinamide away from the salvage pathway.
NNMT is expressed mainly in liver and adipose tissue. Interest in it grew after a 2014 study reported that knocking down NNMT in fat and liver of mice changed tissue SAM and NAD+ levels and energy expenditure on a high-fat diet. That raised the question of whether a small-molecule inhibitor could reproduce those effects in experimental systems.
What researchers study
Work with 5-Amino-1MQ has focused on enzyme inhibition assays, selectivity against related methyltransferases and NAD+ salvage enzymes, cell permeability, and changes in 1-MNA, SAM and NAD+ in cultured adipocytes. Rodent studies have examined adipose tissue and metabolic readouts in diet-induced models. Published data are preclinical, and there are no peer-reviewed human studies.
Regulatory status
5-Amino-1MQ is not approved by the FDA for any use and has not been approved for human use. It is a research reagent only.
Quality & Documentation
Every batch of 5-AMINO-1MQ is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). Each vial is labeled with its batch number and a QR code that opens the testing lab’s own report for that batch. When a batch is in stock, its Certificate of Analysis is posted on this page and in our COA Library, so you can check one against the other.
Research overview
For a longer look at 5-Amino-1MQ, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our 5-Amino-1MQ research overview. It is written as background reading, and every study it cites is linked to PubMed.
Selected literature
- Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262. PMID 24717514
- Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340-353. PMID 28291578
- Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. PMID 29155147
Research Use Only
This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.
