Pinealon

Pinealon

Pinealon is a synthetic tripeptide, Glu-Asp-Arg (EDR), from the family of short “peptide bioregulators” developed by Russian gerontology research groups. With only three residues and a molecular weight near 418 g/mol, it is small enough that researchers have asked whether it can pass cell and nuclear membranes and act directly on gene expression, a question that runs through much of its literature.

Product Specifications

• Product: Pinealon
• Amount: See available options above
• Form: Lyophilized powder
• Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
• Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
• Ships from: United States, 2-day UPS

Chemical Profile

• Compound class: Synthetic tripeptide
• Sequence: Glu-Asp-Arg (3 residues)
• Molecular formula: C₁₅H₂₆N₆O₈
• Molecular weight: 418.4 g/mol
• CAS number: 175175-23-2

What researchers study

Published Pinealon work combines cell biology with rodent stress and injury models:

• Oxidative stress and cell viability: cultured cells exposed to oxidative challenges, with measurements of reactive oxygen species, proliferation and cell survival.
• Prenatal models: rat offspring exposed to experimental hyperhomocysteinemia during gestation, assessed for oxidative markers and later behavior.
• Brain cell cultures: serotonin expression in cortical cell cultures, and caspase-3 activity in the brains of aged rats after carotid occlusion.
• Peptide-DNA interaction: fluorescence-labeled short peptides tracked into the nucleus of HeLa cells, and biophysical studies of how EDR binds DNA and how ions affect that binding.
• Gene regulation hypotheses: modeling work proposing mechanisms by which EDR could influence expression of genes linked to neurodegeneration.

Most of this research comes from one network of laboratories, and many findings have not been independently replicated. Findings in cells and rodents do not establish effects in humans.

Regulatory status

Pinealon is not approved by the FDA for any use. It is sold here as a research reagent only.

Quality & Documentation

Every batch of Pinealon is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). Each vial is labeled with its batch number and a QR code that opens the testing lab’s own report for that batch. The same batch Certificate of Analysis is posted on this page and in our COA Library, so you can check one against the other.

Research overview

For a longer look at Pinealon, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our Pinealon research overview. It is written as background reading, and every study it cites is linked to PubMed.

Selected literature

• Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011;14(5):535-541. PMID 21978084
• Arutjunyan A, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-185. PMID 22567179
• Khavinson VKh, et al. Short peptides stimulate serotonin expression in cells of brain cortex. Bull Exp Biol Med. 2014;157(1):77-80. PMID 24909721
• Khavinson V, et al. EDR peptide: possible mechanism of gene expression and protein synthesis regulation involved in the pathogenesis of Alzheimer’s disease. Molecules. 2020;26(1):159. PMID 33396470

Research Use Only

This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.