Selank

Selank

Selank is a synthetic heptapeptide, seven amino acids long, built on the sequence of tuftsin, a short immunomodulatory peptide (Thr-Lys-Pro-Arg) cleaved from the heavy chain of immunoglobulin G. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it adds a Pro-Gly-Pro tail to the tuftsin core, a change intended to slow enzymatic breakdown. Most of its literature comes from Russian research groups working in rodent and cell models.

Product Specifications

• Product: Selank
• Amount: See available options above
• Form: Lyophilized powder
• Purity: Third-party tested by an ISO 17025 U.S. laboratory. See the batch Certificate of Analysis (COA) on this page.
• Storage: Keep sealed and refrigerated at 2–8°C (36–46°F), protected from light.
• Ships from: United States, 2-day UPS

Chemical Profile

• Compound class: Synthetic heptapeptide (tuftsin analogue)
• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (7 residues)
• Molecular formula: C₃₃H₅₇N₁₁O₉
• Molecular weight: 751.9 g/mol
• CAS number: 129954-34-3

What researchers study

Selank sits at the crossing point of neuropeptide and immune research. Published work centers on a few recurring questions:

• Peptidase inhibition: in-vitro assays with human serum show that Selank, like the related peptide Semax, inhibits enkephalin-degrading enzymes, which links it to the regulation of endogenous opioid peptides.
• Monoamine systems: rodent studies measure serotonin, dopamine and their metabolites in brain tissue, including comparisons between mouse strains and with tuftsin in rats pretreated with the serotonin-synthesis inhibitor PCPA.
• Neurotrophin expression: rat experiments track BDNF expression in the hippocampus after intranasal administration.
• GABAergic and immune genes: expression studies examine genes involved in GABAergic signaling, and stress models look at cytokine levels such as IL-6.
• Brain network imaging: functional connectivity studies compare the effects of Selank and Semax.

The evidence base is small and concentrated in a handful of laboratories. Findings in animal and cell models do not establish effects in humans.

Regulatory status

Selank is not approved by the FDA for any use. It is sold here as a research reagent only, not as an approved drug product.

Quality & Documentation

Every batch of Selank is made in small runs for Rogue Compounds and tested by an independent U.S. laboratory for identity (mass spectrometry) and purity (HPLC). Each vial is labeled with its batch number and a QR code that opens the testing lab’s own report for that batch. The same batch Certificate of Analysis is posted on this page and in our COA Library, so you can check one against the other.

Research overview

For a longer look at Selank, covering where it came from, what cell and animal studies have measured, and what the evidence does not show, read our Selank research overview. It is written as background reading, and every study it cites is linked to PubMed.

Selected literature

• Inozemtseva LS, et al. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Dokl Biol Sci. 2008;421:241-243. PMID 18841804
• Semenova TP, et al. Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA. Eksp Klin Farmakol. 2009;72(4):6-8. PMID 19803361
• Narkevich VB, et al. Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study. Eksp Klin Farmakol. 2008;71(5):8-12. PMID 19093364
• Kost NV, et al. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorg Khim. 2001;27(3):180-183. PMID 11443939
• Panikratova YR, et al. Functional connectomic approach to studying Selank and Semax effects. Dokl Biol Sci. 2020;490(1):9-11. PMID 32342318

Research Use Only

This product is sold strictly as a research chemical for in-vitro laboratory and analytical use by qualified professionals. It is not a drug, dietary supplement, food, or cosmetic, and it is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. Rogue Compounds does not provide dosing, preparation, or usage instructions. The literature on this page is listed for scientific background only and does not describe this product or any use of it.